5/28/2023 0 Comments Anti Deep Ze 7.22We identified that integrin α3 ( ITGA3), integrin α6 ( ITGA6), and tenascin C ( TNC) were coordinately regulated by these miRNAs in HNSCC cells. ![]() Low expression of miR-150-5p and miR-150-3p predicted significantly shorter overall survival in patients with HNSCC ( P = 0.0091 and P = 0.0386) by Kaplan–Meier survival curves analyses. Ectopic expression of mature miRNAs, miR-150-5p and miR-150-3p inhibited cancer cell aggressiveness. Expression of miR-150-5p (guide strand miRNA) and miR-150-3p (passenger strand miRNA) were significantly silenced in cancer tissues, suggesting both miRNAs act as antitumor miRNAs in HNSCC cells. Our signature revealed that a total of 160 miRNAs (44 upregulated and 116 downregulated) were aberrantly expressed in cancer tissues. We adopted into RNA-sequencing technologies to construct the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). ![]() Received: JanuAccepted: MaPublished: March 17, 2017 ![]() Keywords: microRNA, miR-150, ITGA3, ITGA6, TNC Keiichi Koshizuka 1, 2, Nijiro Nohata 3, Toyoyuki Hanazawa 2, Naoko Kikkawa 2, Takayuki Arai 1, Atsushi Okato 1, Ichiro Fukumoto 1, 2, Koji Katada 2, Yoshitaka Okamoto 2, Naohiko Seki 1ġDepartment of Functional Genomics, Chiba University Graduate School of Medicine, Chuo-Ku, Chiba, JapanĢDepartment of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, JapanģMoores Cancer Center, University of California, San Diego, La Jolla, CA, USA
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